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CAS No.154057-58-6 | [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido

CAS No.154057-58-6 | [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido

Name: [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido CAS No. 154057-58-6 MF:C37H30BrFNP MW:618.5169642 Purity:97% Package:10g,25g,50g,100g,250g Worldwide Delivery

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Pharmaceutical Intermediates

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Product introduction

Introduction and application of CAS No. 154057-58-6 | [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido

Synonyms:pitavastatinfluorineisomerimpurity;

[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenyl-phosphoniumbromide(1:1);

Phosphonium,[[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenyl-,bromide(1:1);

[2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-methyl]-3-phenylphosphonium;

PitavastatinCalciumIntermediate;

[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphoniumbromide;

2-Cyclopropyl-4-(4-fluoropenyl)-quinolyl-3-MethyltriphenylBroMide;

PitavastatinInterMediate

Specification:

ITEMS	SPECIFICATION
CAS	154057-58-6
MF	C37H30BrFNP
MW	618.5169642
Melting point	218-225℃
Color	White to off-white
Solubility	Soluble in chloroform (a little), DMSO (a little)
Form	Solid
Storage condition	Inert atmosphere,Room Temperature

Mechanism of action:

The mechanism of action of pitavastatin calcium intermediate is currently believed to be to inhibit the rate-limiting enzyme in the early stage of intracellular cholesterol synthesis, namely HMG-COA reductase, reducing intracellular free cholesterol, which then feeds up to the cell surface low-density lipoprotein ( The expression of LDL) receptors increases the number and activity of cellular LDL receptors, accelerating the clearance of very low-density lipoprotein (VLDL) residual particles or intermediate-density lipoprotein (IDL) and LDL in circulating blood. In addition, it can also inhibit the synthesis of VLDL in the liver, and its effect on reducing total cholesterol (TC) and LDL-C is more obvious. It also reduces triacylglycerol (TG) and increases high-density lipoprotein cholesterol (HDL-C).

Package and transportation :

Package: 10g,25g,50g,100g,250g